Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Siramesine and lapatinib induce synergistic cell death. (a) A549 and U87 were treated for 24 hours with 0.5 μM lapatinib and 10 μM siramesine. Drug-drug interactions were assessed according to the combination index (CI) model. Isobolograms demonstrate the effects of the combination. (b) A549 and U87 were treated for 24 hours with DMSO (D), 0.5 μM lapatinib (L), 10 μM siramesine (S), or the combination of lapatinib+siramesine (L+S). Cell death was quantified by trypan blue exclusion assay using flow cytometry. Standard error represents four independent experiments (). represents statistical significance of .
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