Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

<div>Ferrostatin-1 and DFO partially inhibits lapatinib and siramesine cell death. (a) A549 and U87 cells were pretreated with 10 <i>μ</i>M Fer-1 or (b) 200 <i>μ</i>M DFO for one hour before treatment with DMSO (D), lapatinib (L), siramesine (S), or the combination of lapatinib and siramesine (L+S) for 24 hours. Cell death was quantified by trypan blue exclusion assay using flow cytometry. 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Oxidative Medicine and Cellular Longevity

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Figure 3

Figure 3: Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels 

Figure 3 | Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels 