Antioxidant and Cardioprotective Effects of EPA on Early Low-Severity Sepsis through UCP3 and SIRT3 Upholding of the Mitochondrial Redox Potential

Figure 7

Effects of early low-severity sepsis and dietary eicosapentaenoic acid on myocardial function. LPS: lipopolysaccharides; TLR: Toll-like receptors; NF-κB: nuclear factor-kappa B; IκBα: nuclear factor of kappa light polypeptide gene enhancer in B-cell inhibitor alpha; P: phosphate; IL-1β: interleukin-1β; TNF-α: tumor necrosis factor-alpha; mRNA: messenger ribonucleic acid; EPA: eicosapentaenoic acid; HIF-1α: hypoxia-inducible factor-1-alpha; SOD2: mitochondrial superoxide dismutase; PDK4: pyruvate dehydrogenase kinase 4; HK2; hexokinase 2; PKm: pyruvate kinase; lysine acetylation: image of the beta-oxidation rate; SIRT3: sirtuin-3; UCP3: uncoupling protein 3; CI, CII, CIII, and CIV: complexes 1, 2, 3, and 4 of the respiratory chain; ATPase: adenosine triphosphate synthase; mPTP: mitochondrial permeability transition pore.