Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-<i>κ</i>B/TNF-<i>α</i> Signaling Pathway

<div>EXO prevents cell senescence through the regulation of lncRNA MALAT1. (a) Dual luciferase assay revealed siRNA-MALAT1 reversed the EXO’s effects on NF-<i>κ</i>B activity in H<sub>2</sub>O<sub>2</sub>-treated cells. (b) siRNA-MALAT1 blocked EXO’s effect on p-p65 expression. (c) siRNA-MALAT1 blocked EXO’s effect on TNF-<i>α</i> expression. (d) siRNA-MALAT1 blocked EXO’s effect on p21 expression. (e) Immunohistochemistry staining of <i>β</i>-gal in cardiomyocytes treated with siRNA-MALAT1. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-<i>κ</i>B/TNF-<i>α</i> Signaling Pathway 

Oxidative Medicine and Cellular Longevity

Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome/lncRNA MALAT1/NF-κB/TNF-α Signaling Pathway

Figure 6