Research Article
Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling
Figure 11
Schematic depicting that hyperglycemia-induced oxidative stress compromises RPC cardioprotection in diabetes by impairing Cav-3-modulated PI3K/Akt and JAk2/STAT3 signaling. Antioxidant N-acetylcysteine preserves RPC-induced cardioprotection by improving Cav-3-dependent Akt and STAT3 activation and by facilitating the cross talk between PI3K/Akt and JAK2/STAT3 signaling pathways in diabetes. Solid arrows depict stimulation, while transverse âTâ shape indicates inhibition.