Hyperglycemia-Induced Oxidative Stress Abrogates Remifentanil Preconditioning-Mediated Cardioprotection in Diabetic Rats by Impairing Caveolin-3-Modulated PI3K/Akt and JAK2/STAT3 Signaling
N-Acetylcysteine (NAC) treatment restored remifentanil preconditioning (RPC) in diabetic rats, which was abolished by the inhibition of PI3K/Akt or JAK2/STAT3 signaling. Streptozotocin-induced diabetic rats with or without NAC treatment in the presence or absence of wortmannin (Wort) and AG490 (AG) were subjected to myocardial ischemia/reperfusion (I/R) or RPC. Infarct size (a), plasma CK-MB (b), plasma 15-F2t-isoprostane (15-F2t-IsoP) (c), and cardiac 15-F2t-IsoP (d). All the results are expressed as ,. Differences were determined by one-way analysis of variance (ANOVA) followed by Tukey’s test. and vs. the I/R group; vs. the I/R+NAC group; and vs. the NAC+RPC group.