Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats

<div>Melatonin-induced attenuation of hippocampal neuroinflammation in DSS rats. (a–c) Micrographs depict labeling of GFAP (green) and Iba-1 (red) in rat hippocampal slices. Nuclear staining was performed with DAPI (blue). (d) The number of cells expressing GFAP, a marker of astrocyte activation. (e) The number of cells expressing Iba1, a marker of microglia activation. (f) Hippocampal IL-1<i>β</i> levels of rats measured with ELISA. (g) Hippocampal zonulin levels of rats measured with ELISA. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats 