Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption

Table 2

Gender-adjusted empirical analysis of genetic polymorphisms (covariates) potentially involved in longevity and associated with cardiovascular risk.

SNPs	CENT vs. LCR		CENT vs. HCR		CENT vs. CONT
	OR (95 CI)		OR (95 CI)		OR (95 CI)
ACE (ID) rs4646994
Additive model
DD	Referent		Referent		Referent
ID	0.96 (0.58-1.61)	0.884	2.72 (1.29-5.74)	0.009	1.23 (0.83-1.81)	0.302
II	3.16 (1.44-6.93)	0.004	3.96 (1.83-8.56)	<0.0001	3.43 (1.77-6.64)	<0.0001
Recessive model
DD	Referent		Referent		Referent
II/ID	1.22 (0.75-1.97)	0.420	1.74 (1.10-2.76)	0.018	1.49 (1.03-2.16)	0.036
Dominant model
ID/DD	Referent		Referent		Referent
II	3.22 (1.54-6.76)	0.002	3.20 (1.56-6.58)	0.002	3.07 (1.64-5.73)	<0.0001
AGT (CT), CM920009 rs699
Additive model
CC	Referent		Referent		Referent
CT	1.61 (0.78-3.46)	0.196	0.63 (0.29-1.39)	0.255	0.98 (0.55-1.76)	0.951
TT	—	0.999	3.55 (0.45-28.09)	0.229	1.99 (0.27-14.71)	0.499
Recessive model
CC/CT	Referent		Referent		Referent
TT	—	0.999	3.82 (0.49-29.97)	0.203	2.0 (0.27-14.71)	0.496
Dominant model
CC	Referent		Referent		Referent
CT/TT	1.55 (0.74-3.26)	0.248	0.75 (0.36-1.55)	0.433	1.03 (0.58-1.81)	0.927
AGT (TC), CM920010 rs4762
Additive model
TT	Referent		Referent		Referent
TC	1.53 (0.86-2.72)	0.149	0.74 (0.46-1.20)	0.218	0.98 (0.65-1.47)	0.915
CC	1.94 (0.94-3.99)	0.071	0.91 (0.49-1.71)	0.773	1.178 (0.69-2.00)	0.546
Recessive model
TT/TC	Referent		Referent		Referent
CC	1.46 (0.80-2.67)	0.216	1.08 (0.61-1.91)	0.785	1.19 (0.75-1.90)	0.460
Dominant model
TT	Referent		Referent		Referent
TC/CC	1.62 (0.94-2.82)	0.085	0.78 (0.50-1.23)	0.285	1.03 (0.70-1.51)	0.890
AGR1 (CT) rs5182
Additive model
CC	Referent		Referent		Referent
CT	1.13 (0.66-1.92)	0.655	0.98 (0.61-1.59)	0.945	1.06 (0.71-1.59)	0.763
TT	0.99 (0.51-1.93)	0.978	0.97 (0.52-1.79)	0.920	1.01 (0.61-1.67)	0.977
Recessive model
CC/CT	Referent		Referent		Referent
TT	0.92 (0.51-1.66)	0.789	0.98 (0.56-1.71)	0.937	0.97 (0.62-1.54)	0.908
Dominant model
CC	Referent		Referent		Referent
CT/TT	1.09 (0.66-1.79)	0.748	0.98 (0.63-1.53)	0.926	1.05 (0.72-1.52)	0.812
NOS3 (GT) rs1799983
Additive model
GG	Referent		Referent		Referent
GT	1.19 (0.70-2.04)	0.517	1.35 (0.81-2.24)	0.256	1.28 (0.85-1.94)	0.242
TT	2.14 (1.12-4.10)	0.021	3.11 (1.70-5.70)	<0.0001	2.78 (1.66-4.64)	<0.0001
Recessive model
GG	Referent		Referent		Referent
TT/GT	1.44 (0.88-2.36)	0.148	1.80 (1.13-2.87)	0.013	1.66 (1.14-2.43)	0.009
Dominant model
GT/GG	Referent		Referent		Referent
TT	1.95 (1.09-3.48)	0.024	2.66 (1.55-4.55)	<0.0001	2.43 (1.53-3.87)	<0.0001
GRK4, CM025429 rs2960306
Additive model
GG	Referent		Referent		Referent
GT	1.07 (0.64-1.80)	0.801	0.74 (0.46-1.19)	0.211	0.89 (0.60-1.32)	0.556
TT	1.31 (0.66-2.60)	0.446	0.69 (0.35-1.38)	0.295	0.97 (0.56-1.68)	0.967
Recessive model
GG/GT	Referent		Referent		Referent
TT	1.26 (0.68-2.34)	0.469	0.81 (0.43-1.54)	0.521	1.03 (0.62-1.72)	0.908
Dominant model
GG	Referent		Referent		Referent
GT/TT	0.89 (0.54-1.45)	0.632	0.73 (0.47-1.14)	0.162	0.91 (0.63-1.32)	0.607
GRK4, CM025430 rs1024323
Additive model
CC	Referent		Referent		Referent
CT	1.24 (0.73-2.12)	0.427	0.73 (0.45-1.17)	0.190	0.92 (0.62-1.37)	0.694
TT	1.75 (0.87-3.49)	0.115	0.81 (0.40-1.61)	0.541	1.14 (0.65-1.99)	0.650
Recessive model
CC/CT	Referent		Referent		Referent
TT	1.54 (0.83-2.83)	0.171	0.95 (0.50-1.82)	0.880	1.19 (0.71-1.98)	0.507
Dominant model
CC	Referent		Referent		Referent
CT/TT	1.36 (0.82-2.24)	0.237	0.75 (0.48-1.17)	0.197	0.97 (0.67-1.41)	0.877
SLC12A3 rs13306673
Additive model
CC	Referent		Referent		Referent
CT	0.80 (0.39-1.63)	0.534	1.40 (0.75-2.58)	0.288	1.09 (0.65-1.83)	0.746
TT	—		—	0.999	—	0.999
Recessive model
CC/CT	Referent		Referent		Referent
TT	—		—	0.999	—	0.999
Dominant model
CC	Referent		Referent		Referent
CT/TT	0.80 (0.39-1.63)	0.534	1.47 (0.80-2.69)	0.210	1.14 (0.68-1.90)	0.629

LCR: low cardiovascular risk; HCR: high cardiovascular risk; CENT: centenarians; CONT: controls.