Research Article

The Recombinant Protein EphB4-Fc Changes the Ti Particle-Mediated Imbalance of OPG/RANKL via EphrinB2/EphB4 Signaling Pathway and Inhibits the Release of Proinflammatory Factors In Vivo

Figure 2

The effect of coculture of osteoblasts and osteoclasts on osteoclast function with or without Ti. (a–d) Show bone absorption experiment with or without ephB4-Fc or Ti in the presence of M-CSF and RANKL for 12 days. (e–o) Show the F-actin rings with or without ephB4-Fc or Ti. (p) Shows the histogram of the total area of bone resorption was based on the size of the above pits. (q) Shows the number of F-actin rings in the 5 randomized fields. Data are represented as , (, ).