Oxidative Medicine and Cellular Longevity

Review Article

Efficacy of Curcumin on Aortic Atherosclerosis: A Systematic Review and Meta-Analysis in Mouse Studies and Insights into Possible Mechanisms

Table 1

Characteristics of all included studies.

Studies

Gene modification

Age

Gender

Diet

Route

Source
Purity

Study length

Dosage

Standardized dosage (BW)

Quantification of atherosclerotic lesion

Detection of biochemical indicators

Included groups and sample sizes

Coban 2012

APOE^-/-

8 w

Male

HFD

Chow

Sigma
≥98%

16 w

2000 mg/kg/d dietary

300 mg/kg

Aortic sinus stained with Oil Red O

Lipid markers (Tc, TG)

Model control,
Curcumin,

Hasan 2014

LDLR^-/-

8 w

Male

HFD

Chow

Sigma
≥98%

16 w

500 mg/kg/d dietary

75 mg/kg

Whole aorta stained with Oil Red O

Lipid markers (Tc, TG, HDL)
Inflammation markers (TNF-α, IL-6, IL-1β)

Model control,
Curcumin low,
Curcumin medium,
Curcumin high,

1000 mg/kg/d dietary

150 mg/kg

Whole aorta stained with Oil Red O

1500 mg/kg/d dietary

225 mg/kg

Whole aorta stained with Oil Red O

Li 2019

APOE^-/-

8 w

Male

HFD

i.v.

Sigma
≥98%

30 d

2 mg/kg/3d BW

3.3 mg/kg

Thoracic aorta stained with Oil Red O

Lipid markers (Tc, TG, LDL)

Model control, n = 10
Curcumin-liposomes, n = 10

Meng 2019

APOE^-/-

8 w

Male

HFD

i.v.

10 mg/kg/d BW

16.7 mg/kg

Whole aorta stained with Oil Red O

Lipid markers (Tc, TG, HDL, LDL)
Inflammation markers (TNF-α, IL-6)

Model control,
Curcumin,

Olszanecki
2005

APOE^-/-
LDLR^-/-

8 w

Female

HFD

Chow

Cayman Chemical
≥90%

16 w

0.3 mg/d/mouse BW

10 mg/kg

Whole aorta stained with Oil Red O

Lipid markers (Tc, TG)

Model control,
Curcumin,

Sawada 2012

APOE^-/-

5 w

Male

NCD

Chow

Wako Pure Chemical Industries
≥90%

15 w

5000 mg/kg/d dietary

750 mg/kg

Whole aorta stained with Sudan III

Model control,
Curcumin,

Shin 2014

APOE^-/-

7 w

Male

HFD

Chow

Sigma
≥98%

10 w

50 mg/kg/d dietary

75 mg/kg

Aortic arch stained with Oil Red O

Lipid markers (Tc, TG, HDL, LDL)
Inflammation markers (TNF-α, IL-6)

Model control,
Curcumin,

Wan 2016

APOE^-/-

6 w

Male

HFD

i.g.

Sigma
≥98%

12 w

40 mg/kg/d BW

40 mg/kg

Aortic arch stained with HE

Lipid markers (Tc, TG, HDL, LDL)
Inflammation markers (TNF-α, IL-6)

Model control,
Curcumin low,
Curcumin medium,
Curcumin high,

60 mg/kg/d BW

60 mg/kg

Aortic arch stained with HE

80 mg/kg/d BW

80 mg/kg

Aortic arch stained with HE

Zhang 2018

APOE^-/-

9 w

Male

HFD

Chow

Sigma
≥98%

16 w

1000 mg/kg/d dietary

150 mg/kg

Aortic sinus stained with Oil Red O

Inflammation markers (TNF-α, IL-1β)

Model control,
Curcumin,

Zou 2018

APOE^-/-

9 w

HFD

Chow

Sigma
≥98%

16 w

1000 mg/kg/d dietary

150 mg/kg

Aortic sinus stained with Oil Red O

Lipid markers (Tc, TG, HDL, LDL)

Model control,
Curcumin,

HFD: high-fat diet; NCD: normal chow diet; i.v.: intravenous injection; i.g.: oral gavage; HE: hematoxylin-eosin; Standardized dosage as Sharma [17] has reported.