Review Article

Efficacy of Curcumin on Aortic Atherosclerosis: A Systematic Review and Meta-Analysis in Mouse Studies and Insights into Possible Mechanisms

Table 2

Summary of the anti-inflammation and antilipidemic effect of curcumin.

OutcomeIncluded experimentsMD2% valueEgger’s test

(1) Effect on plasma lipid level
Tc12 [89, 1718, 2930, 3233]179-1.005 (-1.885, -0.124)76.20%0.0250.226
TG12 [89, 1718, 2930, 3233]179-0.045 (-0.088, -0.002)0.20%0.0420.063
HDL9 [1718, 2930, 32]109-0.087 (-0.235, 0.060)9.20%0.2450.975
LDL-c7 [18, 2930, 3233]108-0.523 (-0.896, -0.149)89.10%0.0060.081
(2) Effect on plasma inflammatory responses
TNF-α#6 [18, 2931]88-56.641 (-86.848, -26.433)92.30%<0.0010.036
IL-68 [1718, 2930]89-10.687 (-23.705, 2.331)90.40%0.1080.753
IL-1β4 [17, 31]41-5.089 (-8.559, -1.619)0.00%0.0040.894

Tc: total cholesterol; TG: triglyceride; HDL: high-density lipoprotein; LDL-c: low-density lipoprotein cholesterol; TNF-α: tumor necrosis factor-α; IL-6: interleukin-6; IL-1β: interleukin-1β; : total number of animals in the study; #Two pairwise experiments were omitted; Publication bias existed. represents the significant difference.