Efficacy of Curcumin on Aortic Atherosclerosis: A Systematic Review and Meta-Analysis in Mouse Studies and Insights into Possible Mechanisms

Table 3

Results of metaregression analysis.

		Coef.	95% CI	value	value
Continuous variable
Publication year		0.053	(-0.219, 0.113)	-0.69	0.501
Study length		0.005	(-0.128, 0.137)	0.08	0.937
Age of mice		0.290	(-0.792, 0.213)	-1.25	0.234
Binary variable
Source of curcumin		1.026	(-2.361, 0.310)	-1.67	0.120
Gender of mice		0.519	(-1.154, 2.192)	0.68	0.512
Staining methods		0.545	(-1.817, 1.009)	-0.62	0.545
Multicategorical variable
Assessing location	Arch	0.717	(-2.818, 1.384)	-0.76	0.465	0.7276
	Sinus	0.695	(-2.770, 1.379)	-0.75	0.472
	Whole	0.513	(-1.449, 2.475)	0.58	0.573
Route of curcumin	Chow	0.527	(-1.165, 2.220)	0.69	0.507	0.1776
	Intravenous injection	0.758	(-1.443, 2.959)	0.76	0.464

Coef.: coefficient; CI: confidence interval; Dummy variable was applied for metaregression analysis of multicategorical variable. The former value in metaregression analysis of multicategorical variable represents the comparison of each variable with the control variable (thoracic aorta or oral gavage). The latter value represents a total statistical difference of assessing location area or route of curcumin. was considered to be of statistical difference.