Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus

<div>The effect of melatonin treatment on cellular apoptosis in H9c2 myocytes challenged by high glucose/high fat under hypoxia. (a) Representative images of TUNEL staining of H9c2 cells with or without melatonin and anisomycin treatment. The images with TUNEL staining are displayed in the upper panel. Images with DAPI staining are displayed in the middle panel depicting nuclei of cells. Lower panel indicates the overlay images to illustrate the apoptotic cells. (b) Pooled data depicting the percentage of apoptotic cells. <span class="nowrap"><svg height="9.10327pt" id="M30" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.75334 68.2966 9.10327" width="68.2966pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M861 0V28C774 35 771 41 768 147L759 509C756 612 762 614 851 622V650H681L449 149L221 650H57V622C148 613 153 609 144 479L130 271C123 166 117 123 111 88C104 46 85 34 26 28V0H259V28C192 35 169 42 167 90C166 130 166 173 170 256L185 541H187L411 7H431L675 555H679L683 147C683 41 680 35 598 28V0H861Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.244,0)"><path d="M380 106C343 72 306 56 265 56C195 56 116 112 115 248C235 252 361 262 377 265C396 269 400 277 400 297C400 374 333 449 250 449H249C198 449 144 421 103 376S37 269 37 201C37 88 109 -12 232 -12C263 -12 332 6 395 84L380 106ZM225 412C281 412 315 364 314 312C314 297 308 292 290 292C232 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Melatonin Ameliorates MI-Induced Cardiac Remodeling and Apoptosis through a JNK/p53-Dependent Mechanism in Diabetes Mellitus 