IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer

Figure 2

IMCA inhibited the growth of xenograft in vivo. (a) Representative photographs of tumor-bearing nude mice and tumor volume changes of mice in the experimental period. (b) Tumor weight was determined and compared between the IMCA treatment and control groups. (c) Body weight changes of mice in the experimental period. BUN (d) and ALT (e) were determined and compared between the IMCA treatment and control groups. (f) Liver, renal, and cardiac indices were determined and compared between IMCA treatment groups and controls. (g) RBC, WBC, Lym, and Mon contents were determined and compared between IMCA treatment and control groups. (h) Representative photographs of nontumor-bearing nude mice. (i) Body weight changes of nontumor-bearing nude mice in the experimental period. (j) Liver, renal, cardiac, and spleen indices were determined and compared between the IMCA treatment and control groups. ; .

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)