Research Article

Stanniocalcin-1 Alleviates Contrast-Induced Acute Kidney Injury by Regulating Mitochondrial Quality Control via the Nrf2 Pathway

Figure 6

The protective effects of rhSTC1 on renal function and pathological injury in rat kidneys. The way to build CI-AKI rat model was described in our previous article. rhSTC1 at different concentrations (0.5 μg/rat, 1 μg/rat) and iohexol (200 mg iodine/ml) were administrated through the caudal vein at the same time. (a) Western blot analysis of the expression of cleaved caspase 3 in the whole cells (). (b) Representative images of tubular cell injury in rat kidney tissue and immunofluorescent labeling for TUNEL in rat kidney tissue sections of the four groups (×200). Rat kidney tissue was stained for TUNEL (green). Nuclei were stained with DAPI (blue). (c) Quantification of average Western blot band intensities. (d) Quantitative analysis of histologic scoring. (e, f) Changes in the levels of Scr and BUN. Values were presented as . , compared with the control group. #, compared with the CI-AKI group.
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