Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 3

Research Article

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action

Figure 3

Role of SERCA in compound 4-induced [Ca2+]i increase. Changes in [Ca2+]i were monitored after pretreatment with thapsigargin (TG), followed by addition of 100 μM compound 4 in Ca2+-free medium. Typical [Ca2+]i response to compound 4 after pretreatment of cells with vehicle (black) or with 5 μM thapsigargin (grey) for 15 min. Arrow indicates the time of compound 4 addition. Control is Fura-4 NW loaded cells without stimulator. Values were presented in .

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