Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 2

Research Article

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action

Table 2

The antagonist and agonist effects of 1,4-DHP compounds (1-6) on [Ca2+]i in Fluo-4 NW-loaded SH-SY5Y cells. (Calcium antagonist amlodipine and agonist Bay K8644 were used as reference compounds).

Compound name and No. of studied 1,4-DHPAntagonist activity (IC50, μM)Agonist activity (RFU, 100 μM)

AmlodipineNo effect
1No effect
2No effectNo effect
3No effect
5No effectNo effect
6No effect
Bay K8644No effect

RFU: relative fluorescence units.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.