Oxidative Medicine and Cellular Longevity / 2020 / Article / Tab 2

Research Article

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action

Table 2

The antagonist and agonist effects of 1,4-DHP compounds (1-6) on [Ca2+]i in Fluo-4 NW-loaded SH-SY5Y cells. (Calcium antagonist amlodipine and agonist Bay K8644 were used as reference compounds).

Compound name and No. of studied 1,4-DHPAntagonist activity (IC50, μM)Agonist activity (RFU, 100 μM)

AmlodipineNo effect
1No effect
2No effectNo effect
3No effect
4
5No effectNo effect
6No effect
Bay K8644No effect

RFU: relative fluorescence units.

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