Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts
Table 2
GO-based biological process analysis of proteins whose redox states were rescued by Slc7a11 overexpression in old fibroblasts. Fisher’s exact test values for all the items shown were lower than 0.05.
Term
Count
value
-log10 ( value)
Cell-cell adhesion
11
<0.001
7.197
Translation
11
<0.001
4.274
RNA splicing
8
<0.001
3.526
Tricarboxylic acid cycle
4
<0.001
3.319
Platelet aggregation
4
0.001
2.971
mRNA processing
8
0.002
2.786
RNA secondary structure unwinding
4
0.002
2.757
Translational initiation
4
0.003
2.529
Cellular response to peptide hormone stimulus
3
0.007
2.147
Formation of translation preinitiation complex
3
0.008
2.112
Establishment or maintenance of cell polarity
3
0.009
2.047
Response to virus
4
0.010
1.994
Pentose-phosphate shunt, nonoxidative branch
2
0.026
1.581
Oxidation-reduction process
9
0.027
1.564
Actin cytoskeleton reorganization
3
0.031
1.507
Isocitrate metabolic process
2
0.031
1.503
Proteolysis involved in cellular protein catabolic process
