Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts

Table 3

GO-based molecular function analysis of proteins whose redox states were rescued by Slc7a11 overexpression in old fibroblasts. Fisher’s exact test values for all the items shown were lower than 0.05.

Term	Count	value	-log10 ( value)
Poly(A) RNA binding	39	<0.001	20.191
Cadherin binding involved in cell-cell adhesion	20	<0.001	15.060
Enzyme binding	13	<0.001	5.841
Actin binding	12	<0.001	5.558
Actin filament binding	8	<0.001	5.054
RNA binding	16	<0.001	4.598
Protein complex binding	11	<0.001	4.521
Protein binding	42	<0.001	4.517
Nucleotide binding	25	<0.001	3.935
Protein domain specific binding	9	<0.001	3.682
GTP binding	9	0.001	2.878
ATP binding	19	0.001	2.826
Protein kinase binding	9	0.003	2.540
ATP-dependent RNA helicase activity	4	0.005	2.284
GTPase activity	6	0.006	2.206
Oxidoreductase activity	10	0.006	2.191
ADP binding	3	0.017	1.768
Rac GTPase binding	3	0.022	1.662
Endopeptidase activity	4	0.025	1.610
Nucleoside binding	2	0.027	1.561