Research Article

Redox States of Protein Cysteines in Pathways of Protein Turnover and Cytoskeleton Dynamics Are Changed with Aging and Reversed by Slc7a11 Restoration in Mouse Lung Fibroblasts

Table 5

KEGG pathway analysis of proteins whose redox states were rescued by Slc7a11 overexpression in old fibroblasts. Fisher’s exact test values for all the items shown were lower than 0.05.

TermCount value-log10 ( value)

Carbon metabolism8<0.0014.183
Spliceosome70.0012.972
Tight junction70.0012.873
Citrate cycle (TCA cycle)40.0032.569
Salmonella infection50.0052.317
Proteasome40.0072.147
Biosynthesis of antibiotics70.0111.955
Adherens junction40.0251.597
Biosynthesis of amino acids40.0311.507
Proteoglycans in cancer60.0331.484
Focal adhesion60.0351.453
Ribosome50.0391.414