Hexachloronaphthalene Induces Mitochondrial-Dependent Neurotoxicity via a Mechanism of Enhanced Production of Reactive Oxygen Species

<div>The effect of PCN67 on oxidative and nitrative stress. (a) Differentiated PC12 cells were treated with vehicle and PCN67 for 72 h. ROS generation was assessed with DCFH-DA (10 <i>μ</i>M) using the excitation and emission filters set at 488 nm and 525 nm. Individual data points are shown. (b) The oxidative damage of lipids by reactive oxygen species was assessed by measuring thiobarbituric acid reactive substances (TBARS), and the results are normalized to the protein level. Individual data points are shown. 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Oxidative Medicine and Cellular Longevity

fig7

Figure 7

Figure 7: Hexachloronaphthalene Induces Mitochondrial-Dependent Neurotoxicity via a Mechanism of Enhanced Production of Reactive Oxygen Species 