Research Article
Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α
Figure 1
BACE1 expression increases in the hippocampi from AD patients. (a) The expression of BACE1 was studied by immunohistochemical analysis in hippocampal sections from nondemented controls and AD patients at the initial stages of the disease (Braak stage II) and late stages of the disease (Braak stage VI). Here, we show the representative images obtained in two different individuals from each group. The expression of BACE-1 (brown) was predominant along the axons from AD patients as indicated by black arrows. Bars represent 200 μm. (b) BACE1 expression was also studied by western blot from hippocampal samples of nondemented controls and AD patients. Data are expressed as A.U. and represent of 4 samples per each group. vs. nondemented controls by Student’s -test. BACE1 bands correspond to the mature glycosylated enzyme (70 kDa) and the immature enzyme (~60 kDa).
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