Integrative Analysis of Lipid Profiles in Plasma Allows Cardiometabolic Risk Factor Clustering in Children with Metabolically Unhealthy Obesity
Table 3
Irisin and cytokines concentration (pg/mL) in children with NW, MHO, and MUO.
NW ()
MHO ()
MUO ()
value
Irisin
8.05 (7.3-8.95)
6.15 (4.1-6.9)
6.4 (5.8-7)
<0.0001
IL-1β
0.3 (ND-0.3)
0.3 (0.3-0.3)
0.3 (0.3-0.55)
0.5897
IFN-α
6.15 (2.8-12.8)
5 (1.3-49.35)
5 (2.4-22.4)
0.8974
IFN-ɣ
11.5 (0.4-17.7)
16.85 (6.4-29.7)
18.1 (6.5-28.15)
0.0456
TNF-α
0.7 (0.4-0.7)
4.3 (0.7-14)
2.1 (0.7-13.28)
0.0003
MCP-1
152.8 (115.3-217.7)
188.1 (143.9-242)
220.3 (154-255.5)
0.0318
IL-6
1 (0.5-3.7)
3.5 (0.5-9)
2.4 (1.1-5.6)
0.0278
IL-8
1.3 (0.6-2.6)
3.1 (1.5-8.6)
3.9 (1.1-6.7)
0.0032
IL-10
1.35 (0.6-2.7)
3.15 (1.3-4.5)
3.1 (0.6-5.9)
0.0093
IL-12
0.9 (0.7-1.9)
2.65 (1.2-3.5)
2.3 (0.8-3.5)
0.0013
IL-17A
0.3 (0.3-0.3)
5.45 (0.35-15.23)
4.25 (0.3-22.4)
<0.0001
IL-18
84.45 (50.25-167)
121.8 (81.8-212.5)
145.1 (110.7-199.8)
0.0124
IL-23
2.85 (0.3-4.8)
8.6 (4.85-14.3)
8.3 (5.1-16.4)
<0.0001
IL-33
3.6 (3.6-18.5)
63.95 (20.8-155.2)
54.65 (38.7-121.1)
<0.0001
Data is presented as median and interquartile range for nonparametric data and as for parametric data. Tests performed with ANOVA/Bonferroni or Kruskal-Wallis/Dunn as described in Methods. Statistical difference vs. NW is represented with . IL: interleukin; TNF: tumor necrosis factor; IFN: interferon; MCP: monocyte chemoattractant protein; MHO: metabolically healthy obesity; MUO: metabolically unhealthy obesity; NW: normal weight.
