Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation

Figure 10

The protection mechanism of GPS-mediated Nrf2 for NAFLD. GPS promoted the phosphorylation of PI3K and AKT and the increase of Nrf2 from cytoplasm to nuclear; however, the PI3K/AKT signaling pathway activation could not help Nrf2 expression in the nucleus and inhibit hepatic lipogenesis.