Gentiopicroside Ameliorates Oxidative Stress and Lipid Accumulation through Nuclear Factor Erythroid 2-Related Factor 2 Activation

Figure 5

Antioxidative stress and antilipogenesis effects of GPS-mediated Nrf2 on FFA-stimulated lipid deposition in HepG2 cells. Nrf2^-/- cells were subjected to 200 μM GPS for 1 h; after that, those cells were incubated with 1 mM FFA for 24 h. (a–g) The expressions of Nrf2, HO-1, NQO1, GCLM, PPARα, and SREBP-1c were detected by Western blot and quantified by densitometric analysis. All data are presented as (three independent experiments). ^# and ^## vs. control group; vs. FFA-stimulated group.

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