Research Article
lncRNA OTUD6B-AS1 Exacerbates As2O3-Induced Oxidative Damage in Bladder Cancer via miR-6734-5p-Mediated Functional Inhibition of IDH2
Figure 2
lncRNA OTUD6B-AS1 exacerbates As2O3-induced cytotoxicity in vivo. (a) Harvested xenotransplanted tumors following lncRNA OTUD6B-AS1 overexpression or treatment with 5 mg/kg As2O3. (b) Volume and (c) weight of the harvested tumors. (d) Levels of lncRNA OTUD6B-AS1 in harvested transplanted tumors determined by qRT-PCR. Bladder cancer xenograft tumors were stained with (e) H&E and (f) TUNEL. Scale bar: 50 μm. (g) Statistical analysis of cells positive for TUNEL staining in bladder cancer xenotransplanted tumors. Bladder cancer xenograft tumors were evaluated by immunohistochemistry staining using antibodies against (h) Ki-67 and (i) p57. Scale bar: 50 μm. , vs. control xenotransplanted tumors; #, ## vs. transplanted tumors with lncRNA OTUD6B-AS1 overexpression; &, && vs. transplanted tumors treated with 5 mg/kg As2O3.
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