Mechanisms of the Regulation and Dysregulation of Glucagon Secretion

Figure 3

Suggested reaction of proline residue (a) with singlet oxygen (¹O₂) to form hydroperoxide (b), which reacts with H₂O to form hydroxy-derivative (c) and hydroperoxide anion (HOO –), followed by reaction of the latter two to form glutamate 5-semialdehyde residue (d).