Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease

Table 3

Performance summary corresponding with the results obtained for all Random Forest models.

Enzyme	Validation	Accuracy	Sensitivity	Specificity	PPV	NPV	MCC
JNK-3	Test	0.89	0.91	0.87	0.86	0.91	0.78
	Cross	0.83	0.85	0.82	0.81	0.85	0.67
PTP1B	Test	0.81	0.81	0.81	0.82	0.80	0.62
	Cross	0.82	0.82	0.82	0.83	0.81	0.64
NFR2	Test	0.76	0.75	0.76	0.86	0.61	0.50
	Cross	0.73	0.78	0.63	0.80	0.60	0.41
NOX1	Test	0.82	0.76	0.91	0.92	0.73	0.67
	Cross	0.80	0.89	0.66	0.92	0.73	0.58
PDE5	Test	0.87	0.9	0.84	0.85	0.9	0.75
	Cross	0.86	0.88	0.85	0.85	0.87	0.73
COX2	Test	0.78	0.83	0.71	0.77	0.78	0.55
	Cross	0.76	0.81	0.7	0.76	0.76	0.52
iNOS	Test	0.81	0.87	0.74	0.78	0.84	0.62
	Cross	0.8	0.85	0.74	0.78	0.82	0.60