Research Article

Identification of New Targets and the Virtual Screening of Lignans against Alzheimer’s Disease

Table 6

Potentially active lignans, multitarget for four or more enzymes, based on the RF and docking model. In bold are the active enzymes that walk in the applicability domain.

IDMultitarget
JNK-3PTP1BPDE5COX-2iNOSNFR2NOX1NQO1

050.390.680.520.410.620.540.170.475
060.380.670.490.430.590.570.510.354
070.450.660.560.530.700.590.250.494
110.350.640.480.460.530.530.630.384
120.370.620.510.480.600.600.250.644
130.320.620.590.460.570.510.450.724
140.510.620.540.450.620.600.250.455
190.310.590.480.490.560.560.510.354
330.410.530.510.500.510.580.410.395
340.350.530.500.430.540.560.450.405
350.270.520.590.460.490.610.700.565
380.540.520.690.510.660.520.311.005
390.540.520.680.610.650.610.330.814
410.590.520.610.600.540.580.330.674
420.520.520.640.590.620.570.360.784
440.350.510.520.450.580.540.430.504
450.450.510.520.490.550.540.350.474
470.390.500.560.470.540.560.360.564
520.450.480.490.500.690.540.450.384
1040.420.400.550.510.310.590.300.504
1060.480.400.580.570.520.560.250.634
1080.530.400.560.450.640.500.380.664
1150.310.390.520.510.610.520.280.524
1340.260.360.500.400.510.560.710.385
1410.400.350.540.500.500.620.520.405
1420.370.350.500.510.650.550.300.404
1460.400.330.570.560.660.550.270.604
1530.490.320.600.500.630.520.390.744