Amarogentin from Gentiana rigescens Franch Exhibits Antiaging and Neuroprotective Effects through Antioxidative Stress

Figure 4

Effect of amarogentin on the replicative lifespans of sod1 (a), sod2 (b), uth1 (c), and skn7 (d) mutant yeast strain with K6001 background. The average replicative lifespans of the wild-type K6001 yeast were generations under the control treatment, generations under the RES treatment, and generations under the 3 μM amarogentin treatment. The average replicative lifespans of the sod1 mutant were generations under the control treatment, generations under the RES treatment, and generations under the 3 μM amarogentin treatment. The average replicative lifespans of the sod2 mutant were generations under the control treatment, generations under the RES treatment, and 7.7 ± 0.2 generations under the 3 μM amarogentin treatment. The average replicative lifespans of the uth1 mutant were 10.8 ± 0.1 generations under the control treatment, generations under the RES treatment, and generations under the 3 μM amarogentin treatment. The average replicative lifespans of skn7 were generations under the control treatment, generations under RES treatment, and generations under 3 μM amarogentin treatment.

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