Oxidative Medicine and Cellular Longevity / 2020 / Article / Fig 4

Research Article

Anethole Dithiolethione Increases Glutathione in Kidney by Inhibiting γ-Glutamyltranspeptidase: Biochemical Interpretation and Pharmacological Consequences

Figure 4

Representative immunohistochemical detection of GSH in rat kidney. Rats were orally administered 1 mg/kg/day ADT or vehicle. After 3-weeks treatment, the right kidney was excised for immunohistochemical evaluation. Constitutive distribution of GSH can be appreciated in proximal (P) and distal (D) tubules (arrows) in tissue sections from control rats (a). Only a faint reaction for GSH can be found in glomeruli from control rats treated with the solvent. A more intense and diffuse positive reaction is evident in proximal (P) and distal (D) tubules (arrows) from kidneys of GSH-treated rats (b). The immune reaction can be also appreciated in epithelial parietal cells of Bowman’s capsule (EP) in kidney sections from treated rats..

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