Anethole Dithiolethione Increases Glutathione in Kidney by Inhibiting γ-Glutamyltranspeptidase: Biochemical Interpretation and Pharmacological Consequences
GSH metabolism in isolated perfused rat kidney treated with glutathione alone or in association with acivicin or probenecid. Isolated rat kidneys were perfused for 2 hours with 10 μM GSH () 20 μM GSH (), 20 μΜ probenecid (), 20 μΜ acivicin (). Urine was collected by cannulating ureter. Samples were collected at 30, 60, and 90 minutes from the beginning of the perfusion from the reservoir connected to the renal artery and from the renal vein outflow for GSH analyses and calculation of its extraction rate. Urinary tGSH values are expressed as nmoles/mg creatinine, vs. GSH 10 μM group.
GSH 10 μM
GSH 20 μM
Extraction % (30)
Abbreviations: GSH: glutathione; tGSH: total glutathione.
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.