Follistatin-Like 1 Protects against Doxorubicin-Induced Cardiomyopathy through Upregulation of Nrf2

Figure 4

FSTL1 overexpression reduced DOX-induced myocardial oxidative damage. (a) The mRNA levels of TNF-α and IL-1β ( for each time point). (b) Myocardial TNF-α and IL-1β levels were determined by ELISA (). (c) Protein expression of Nrf2 in the heart (). (d) The mRNA levels of SOD1 and SOD2 (). (e) Mitochondrial complex activities (). (f) Alterations in SOD activity (). (g, h) MDA and 4-HNE levels (). The data are expressed as the . vs. the NS/con group; ^# vs. the DOX/con group. The data were analyzed using one-way ANOVA, followed by Tukey’s post hoc analysis.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)