Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis

Table 2

Curcumin alters miRNAs and relevant target expression in pancreatic, colorectal, breast, and lung cancers.

Cancer origin	Upregulated	Downregulated	Targets	Refs.
Pancreas	miR-22	miR-21	SP1, ESR1	[220]
	miR-200	miR-199a	PTEN	[221]
Colorectum	—	miR-21	AP1, Pdcd4	[222]
Breast	miR-15a	—	Bcl-2	[223]
	miR-16	—
Lung	mir-206	—	PI3K/AKT/mTOR	[224]
Lung	miR-186	—	Caspase-10	[191]
Retinoblastome	—	miR-99a	JAK/STAT	[225]
Thymic carcinoma		miR-27a	Notch1/mTOR	[226]
Osteosarcoma	—	miR-21	RECK	[227]
Retinoblastome	miR-22	—	Erbb3	[228]

Additionally, curcumin regulates many other miRNA expressions, e.g., miR-1, miR-7, miR-9, miR-19, miR-34a, and miR-181 [193].