Research Article
Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation
Figure 3
ER stress is activated by THIO. (a, b) Expression of ATF6 (~90 kDa) and cleaved ATF6 (~50 kDa) after THIO incubation for 24 h. THIO significantly improved the expression of cleaved ATF6, while ATF6 was logically reduced. vs. control. . (c–f) Representative bands and statistics of calnexin, calreticulin, GRP78, and PDI. THIO increased the expression of these four chaperones. vs. control. .
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