SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes
The specific increase of SOCS2 in adipose tissue after leptin administration. Mice were intraperitoneally injected with leptin (1 mg/kg body weight) or saline. (a) Rectal temperature of male mice was measured after leptin or saline treatment (). (b). Effect of leptin on food intake. Food intake was measured daily during leptin injection study (). (c and d) Serum TG and FFA levels of mice after leptin or saline injection (). Effects of leptin on FABP4 (e), PGC-1α (f), CPT-1b (g), p-ACC (h), and FATP1, FAS, and FAT (i). Protein expression levels of inguinal adipose tissue after leptin or saline injection (). (j) mRNA levels of SOCS1, SOCS2, and SOCS3 of inguinal adipose tissue after leptin or saline injection (). All the protein levels (e–i) were detected by the ELISA test. Values are the .,.
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