Research Article

Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model

Table 1

Mammary tumor occurrence in Group 1: histological features, tumors location, and size; non-mammary tumors detected.

Rat no.Group 1 (MNU)
Mammary tumor typeMammary tumor size (cm)MTM(%)1 relative to FBW2Other tumor types

1Invasive tubular carcinoma, G-1 (M1 right)1.3/1.317.39
Carcinosarcoma, G-1 (M4 right)3.5/2.6
Invasive tubular carcinoma, G-1 (M2 left)1.3/2.1
Invasive tubular carcinoma, G-1 (M5 left)6.8/3.5

2Invasive cribriform carcinoma, G-1 (M1 right)1.4/110.78Interstitial renal tumor (1.3/1 cm)
Ductal in situ cribriform carcinoma, G-1 (M2 right)1.7/1.2
Invasive tubular carcinoma, G-2 (M3 right)6.0/3.5
Invasive tubular carcinoma, G-1 (M5 right)1.7/1.2
Ductal in situ cribriform carcinoma, G-2 (M2 left)2.4/2.2
Invasive tubular carcinoma, G-1 (M3 left)2.1/2.0
Invasive tubular carcinoma, G-1 (M5 left)1.3/0.9

3Ductal in situ cribriform carcinoma, G-1 (M1 right)3/2.529.27
Invasive tubular carcinoma, G-1 (M3 right)3.5/3
Ductal in situ solid carcinoma, G-1 (M4 right)2.5/2.2
Invasive tubular carcinoma, G-1 (M5 right)1.3/1.2
Invasive tubular carcinoma, G-1 (M1 left)2.5/2
Fibroadenoma (M2 left)5/4.5
Ductal in situ papillary carcinoma, G-1 (M3 left)6.5/5.1
Invasive tubular carcinoma, G-1 (M4 left)6.2/5.6
Ductal in situ papillary carcinoma, G-1 (M5 left)4/3.5

4Ductal in situ solid carcinoma, G-3 (M2 right)0.8/0.523.87Malignant lymphoma (diffuse in both mammary chains)
Ductal in situ cribriform carcinoma, G-1 (M5 right)7.9/6.5
Ductal in situ comedo-carcinoma, G-2 (M2 left)3/2.7
Ductal in situ papillary carcinoma, G-1 (M4 left)5.4/3.2

5Fibroadenoma (M4 right)1.7/1.40.25

6Ductal in situ cribriform carcinoma, G-2 (M1 right)0.8/0.64.76
Invasive tubular carcinoma, G-2 (M3 left)4.2/3.7

7Invasive tubular carcinoma, G-1 (M1 right)1.2/0.50.97
Adenoma (M2 right)1.1/1
Adenoma (M2 left)1.0/0.7
Invasive papillary carcinoma, G-1 (M3 left)0.9/0.9
Invasive tubular carcinoma, G-1 (M4 left)0.9/0.6

8Invasive tubular carcinoma, G-2 (M2 right)1.3/1.21.82
Invasive tubular carcinoma, G-1 (M2 left)2.8/2.3

9Liposarcoma in the omentum (1.7/1.2 cm)
Ovarian fibrosarcoma (1.5/1.2 cm)

10Invasive tubular carcinoma, G-2 (M3 right)1.2/1.20.95
Fibroadenoma (M1 left)1.4/1.2
Ductal in situ cribriform carcinoma, G-1 (M5 left)1.2/1

1MTm: mammary tumor mass; 2FBW: final body weight; MNU: N-methyl-N-nitrosourea; M1-5: mammary gland number and its side (i.e., right, left); G: histological grade.