Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model

Table 2

Chemopreventive effects of propolis on mammary tumor occurrence in Group 2: histological features, tumors location, and size; non-mammary tumors detected.

Rat no.	Group 2 (MNU+PE)
	Mammary tumor type	Mammary tumor size (cm)	MTM(%)^1 relative to FBW^2	Other tumor types
1	Invasive cribriform carcinoma, G-1 (M1 left)	1.5/1.5	22	—
	Invasive cribriform carcinoma, G-3 (M2 left)	4.5/3
	Invasive cribriform carcinoma, G-2 (M5 left)	7.5/4.4
2	Invasive tubular carcinoma, G-2 (M4 left)	3.5/2.4	32.8	Rhabdomyosarcoma (diaphragm)
	Invasive tubular carcinoma, G-2 (M5 left)	4.5/2.2
	Invasive tubular carcinoma, G-1 (M1 right)	1.5/0.8
3	Invasive tubular carcinoma, G-2 (M1 right)	2.5/2.8	1.33
	Invasive papillary carcinoma, G-2 (M1 left)	1.1/0.6
4	Invasive tubular carcinoma, G-3 (M1 left)	1/0.7	5.78	—
	Invasive tubular carcinoma, G-3 (M2 left)	5.5/3.2
5	—	—	—	—
6	—	—	—	—
7	Invasive tubular carcinoma, G-1 (M2 right)	3.5/3.2	11.56	Squamous carcinoma (facial skin)
	Invasive tubular carcinoma, G-2 (M4 right)	5/3.5
	Invasive tubular carcinoma, G-1 (M2 left)	3.5/1.5
	Invasive tubular carcinoma, G-1 (M4 left)	5.2/2.5
8	Ductal in situ cribriform carcinoma, G-1 (M4 right)	1.1/0.6	0.55
	Invasive tubular carcinoma, G-1 (M2 left)	1.8/1.3
9	Fibroadenoma (M4 right)	1.2/1.1	0.22	—
	Fibroadenoma (M1 left)	1.1/1
10	—	—	—	—

¹MTm: mammary tumor mass; ²FBW: final body weight; MNU: N-methyl-N-nitrosourea; PE: propolis; M_1-5: mammary gland number and its side (i.e., right, left); G: histological grade.