Research Article

Cerebral Mitochondrial Function and Cognitive Performance during Aging: A Longitudinal Study in NMRI Mice

Table 5

Results from longitudinal studies (A) and single point studies (B) focused on the results of mitochondrial bioenergetics and cognitive functions. Unless otherwise stated, 3-month-old animals served as young controls. Arrows indicate the age at which significant effects were first observed (↑ increase, ↓ decrease, and ↔ no significant effect).

MMPATPCICIVCognitive functionMouse strainLit.

(A) Longitudinal studies
Current study↓ (24 m)↓ (18 m)↓ (12 m)↓ (12 m)↓ (12 m)NMRI
Navarro et al. 2005n.d.↔ (13 m)
↔ (19 m)
↑ (13 m)
↓ (19 m)
↓ (13 m)
↓ (19 m)
n.d.CD-1[44]
Kwong et al. 2000n.d.n.d.↔ (13 m)
↔ (29 m)
↔ (13 m)
↔ (29 m)
n.d.C57Bl/6[45]
Lamberty et al. 1990n.d.n.d.n.d.n.d.↓ (9 m)
↓ (12 m)
NMRI[43]
Gower et al.1993n.d.n.d.n.d.n.d.↓ (9 m)
↓ (12 m)
NMRI[36]
(B) Single point studies
Reutzel et al. 2018↓ (18 m)↓ (18 m)NMRI[28]
Hagl et al. 2016↓ (18 m)↓ (18 m)↓ (18 m)NMRI[27]
Afshordel et al. 2015n.d.↓ (24 m)↔ (24 m)↔ (24 m)n.d.NMRI[46]
Hagl et al. 2015↔ (18 m)↓ (18 m)↔ (18 m)n.d.NMRI[47]
Stoll et al. 1996n.d.n.d.n.d.n.d.↔ (12 m)
↔ (22 m)
NMRI[48]

n.d.: not determined.