Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3<i>β</i> Pathway in Experimental Models of Alzheimer’s Disease

<div>Effects of SF on the regulation of PI3K/Akt/GSK-3<i>β</i> in the STZ-treated rats. (a) Representative immunoblot bands for p-Akt (S473), Akt, p-GSK-3<i>β</i> (S9), GSK-3<i>β</i>, and <i>β</i>-actin in rat hippocampus. (b, c) Quantitative analysis of immunoblot bands. Protein expression levels were normalized to <i>β</i>-actin. 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312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.049,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> when compared with the STZ-treated control group.</div>

Oxidative Medicine and Cellular Longevity

fig8

Figure 8

Figure 8: Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3<i>β</i> Pathway in Experimental Models of Alzheimer’s Disease 

Figure 8 | Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer’s Disease 