PARK7 Diminishes Oxidative Stress-Induced Mucosal Damage in Celiac Disease

Figure 2

Effect of Comp23 on ROS accumulation inFHs71Int cells. FHs74Int duodenal epithelial cells were treated with different concentrations of H₂O₂ in the absence or presence of Comp23 (0.001 μM). Scatter plot (a) serves as a representative figure of the time-related fluorescence intensity after treatment with 1000 μM H₂O₂ with or without Comp23. Violin plot (b) indicates the slope distribution of time-related DCFDA fluorescence intensity change in the given group at different concentrations of H₂O₂. Relative mRNA expressions (c) at 1000 μM H₂O₂ concentration were determined by comparison with 18S ribosomal RNA as an internal control. Results are presented as (). vs. Ø compound at the concerning H₂O₂ concentration (multiple -test); vs. control+Ø compound (Mann-Whitney test); vs. H₂O₂+Ø compound (Mann–Whitney test).

(a)

(b)

(c)