Research Article

The Activation of Phosphatidylserine/CD36/TGF-β1 Pathway prior to Surgical Brain Injury Attenuates Neuroinflammation in Rats

Figure 5

Effects of CD36 siRNA and rAnnexin V on PS liposome pretreatment-induced neuroprotection at 24 h post-SBI. (a) CD36 siRNA or rAnnexin V reversed the Garcia scores improvement associated with the PS liposome pretreatment; (b–f) Western blot assay showed that PS pretreatment significantly increased the level of CD36 and TGF-β1, which was associated with less IL-1β and TNFα expressions. CD36 siRNA or rAnnexin V significantly abolished anti-inflammation associated with PS liposome pretreatment. . , vs. sham, &&, & vs. SBI+vehicle; ##, # vs. SBI+CD36 siRNA+PS; @@, @ vs. SBI+Annexin+PS.
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