GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine

Figure 1

GPA attenuates DSS-induced colitis in vivo. Mice were treated with 3% DSS in their drinking water for 7 days to induce acute colitis. GPA (100 mg/kg) was administered for 7 days before and during DSS treatment via oral gavage once per day. Mice (/group) were sacrificed at day 14. Weight of mice during the experiment (a). Disease activity index (DAI) during the disease process (b). The lengths of the colons from each group of mice were measured (c). The colons from each experimental group were processed for histological evaluation by H&E staining; histopathological scores of each group were determined (d, e). Globe cells were determined by periodic acid-Schiff (PAS) staining (f). The results are expressed as the (/group). , , and vs. the control group; ^#, ^##, and ^### vs. the DSS-treated group.

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