Research Article

Protective Effect of Astragaloside IV on High Glucose-Induced Endothelial Dysfunction via Inhibition of P2X7R Dependent P38 MAPK Signaling Pathway

Figure 2

Effect of As-IV on inflammation and oxidative stress in STZ-induced diabetic rats. (a–e) The expression level of IL-6, TNF-α, IL-1β, and IL-18 proteins and the activity of GSH-px were measured by ELISA (). (f) The level of SOD in the aortas was measured using a SOD assay kit (). (g, h) The level of ROS was determined by DHE staining (). DAPI (blue), DHE dye (red), and elastin autofluorescence signals (green). vs. control group. #, ##, vs. DM group.