Functional Redox Proteomics Reveal That Salvia miltiorrhiza Aqueous Extract Alleviates Adriamycin-Induced Cardiomyopathy via Inhibiting ROS-Dependent Apoptosis

Figure 6

Schematic diagram of ADR-mediated cardiomyopathy through suppression of antioxidant enzymes and inducing oxidative modification of specific proteins involved in mitochondria metabolism. SMAE application could protect the heart cells against ADR damage via enhancement of antioxidant system as well as inhibition of ERK/p53- and cathepsin B/AIF-mediated apoptotic cascades.