Nrf2 and STAT3 Alleviates Ferroptosis-Mediated IIR-ALI by Regulating SLC7A11

Figure 6

The activation of STAT3 in OGD/R-induced MLE12 ferroptosis was regulated by Nrf2. (a) Cells were transfected with Nrf2 interfering lentiviruses and then subjected to OGD/R. The level of GPX4, STAT3, and pSTAT3 expression was measured by western blot. , , , ^#, ^##, and ^### between the groups. Compared with the control group; ^#shNC group compared with the shNrf2 group. (b) Cells overexpressing Nrf2 and then subjected to OGD/R. The level of GPX4, STAT3, and pSTAT3 was measured by western blot. , , , ^#, ^##, and ^### between the groups. Compared with the control group; ^#shNC group compared with the shNrf2 group.

(a)

(b)