The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling
The effect of 4-HPPP on cell cycle progression. (a) The accumulation of sub-G1 and aneuploidy (N>4N) in NSCLC cells. H1299 cells were seeded and treated with different concentrations of 4-HPPP for 48 and 72 h. The treated cells were 70% ethanol-fixed and PI-stained and then subjected to a cell cycle distribution analysis by flow cytometry. Changes in cell cycle progression, the sub-G1 population, and aneuploidy following 4-HPPP treatment. (b) Quantitative analysis of cell cycle progression. ;.
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