The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling
4-HPPP-induced activation of DNA damage markers in NSCLC cells. (a) H1299 cells were seeded and treated with 4-HPPP for 48 h. Afterward, the DNA damage induced by 4-HPPP was assessed by flow cytometry. The markers of DNA damage, including phosphor-ATR, phosphor-ATM, and DNA-PK, were determined. The results showed that 4-HPPP increased the phosphorylation of ATR and ATM and the protein level of DNA-PK in a dose-responsive manner. (b) The quantitative results of (a). ;.
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