The Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling

Figure 9

Effect of 4-HPPP on zebrafish-based xenografted NSCLC cells. (a) Survival rate of zebrafish larvae following 4-HPPP exposure. (b) The results showed that 5 μM and 10 μM 4-HPPP caused body axis bending and edema in zebrafish larvae, indicating that a high concentration of 4-HPPP could cause deformation and toxicity toward zebrafish larvae. (c) The motility of xenografted H1299 cells in the yolk sac of zebrafish larvae. The intensity of red fluorescence is proportional to the xenograft tumor size. For each group, the . (d, e) Quantitative analysis of (c). The data are presented as the . and against vehicle control. (e) The statistical analysis of the migration ability of xenografted H1299 cells using Fisher’s exact test.

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