Research Article
Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons
Figure 2
The effect of glutamate on different IGF-1R tyrosine residues. Following pretreatment with 1 mM glutamate, cultured cortical neurons were exposed to 100 ng/ml IGF-1 for 8 min (for tyrosine phosphorylation of IGF-1R). Different primary antibodies of specific tyrosine residues of IGF-1R were used to test the influence of glutamate on IGF-1R. Data represent assays from at least three independent experiments. .
(a) |
(b) |
(c) |
(d) |
(e) |